Stabilized HOCl is in the form of a physiologically balanced solution in 0.9% saline at a pH range of 3.5 to 4.0. HOCl is the predominant species at the pH range of 3 to 6. At pH values less than 3.5, the solution exists as a mixture of chlorine in aqueous phase, chlorine gas, trichloride (Cl3−), and HOCl. At pH greater than 5.5, sodium hypochlorite (NaOCl) starts to form and becomes the predominant species in the alkaline pH. To maintain HOCl solution in a stable form, maximize its antimicrobial activities, and minimize undesirable side products, the pH must be maintained at 3.5 to 5. Our product is stable within this range. Stable HOCl is an effective and safe compound, and stable for human and animal use at various PPM. At a pH 3 or below HOCl exists in solution with hydrochloric acid and chlorine (HCl and Cl2, respectively). In solutions where the pH is 7.5 or greater HOCl solutions contain more hypochlorite (–OCl). Eventual reduction of oxidative chlorine to the chloride ion (Cl–) leads to a decrease in antimicrobial activity over time in conventionally prepared HOCl solutions, and are described as “highly unstable” . Products supplied by Fulvic Health Pty Ltd are batch tested during the process and at the end of production with a target tight range at 5.5 to 5.8 pH.
Can HOCl inactivate Prion Activity and the deadly pathogen?
As a synthetic preparation, our HOCl is effective as a microbial disinfectant. Prions are deadly pathogens that are notoriously difficult to inactivate and often standard protocols today are inadequate. Treatment with sodium hypochlorite bleach and sodium hydroxide are damaging and unsuitable. The tests done on a HOCL formulation poses no apparent hazard to either users or surfaces. It can be applied directly to the skin and mucous membranes and well as surfaces and entire rooms/stables or clinics without apparent deleterious effects. HOCl can inactivate a range of target microbes, including spores of Bacillus subtilis, but also prions in tissue suspensions and on stainless steel. Reports have documented the increasing evidence that subtypes of dementia, including Alzheimer’s, may have an infectious component that currently looks like a prion-related protein (Abbott, 2015). Having a disinfectant that can eradicate that risk from surgical instruments and medical facilities is a timely finding and in fact a welcome advance in infection control technology. The additional protein denaturing activity of HOCl and in particular, its inactivation of prion proteins, also suggests new opportunities for the design and execution of disease control measures in healthcare institutions (Hughson et al., 2016). Prion infectivity is especially concerning as prions are known to be both potentially pervasive and exceptionally difficult to eradicate (Abbott, 2015).
How is HOCI considered a microbicidal?
The fields of environmental hygiene, disinfection, food safety, and sanitation are now likely to benefit from HOCl as an untapped resource in infection control. HOCl are microbicidal in vitro to fungi, such as Candida albicans, and to many species of bacteria, including methicillin-sensitive (MSSA) and methicillin-resistant (MRSA) Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus saprophyticus, Streptococcus pyogenes, vancomycin-resistant Enterococcus faecium, Serratia marcescens, Escherichia coli, Enterobacter aerogenes, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, and Haemophilus influenza, as referenced in scientific data substantiating further that it is a wound care agent
How does work as an oxidizer?
HOCl is a more powerful oxidizer than chlorine and a very effective sanitizing agent. It is used to make sodium hypochlorite (NaOCl) and calcium hypochlorite, (Ca(OCl)2), which are used in the making of bleaches. This highly effective surface disinfection and cleaning agent is suitable for use in restaurants, kitchens or sales rooms. Disease-causing germs, such as the Aspergillus Brasiliensis, are repulsed effectively.
Can HOCl help with itch and Pruritus?
Pruritus is the most common symptom seen in dermatologic disease. HOCl is anti-inflammatory and reduces the activities of histamine, leukotriene B4, and interleukin-2, all of which are implicated in the pathophysiology of itch. HOCl may reduce pruritus either through its microbicidal effects upon cutaneous pathogens (especially Staphylococcus aureus in atopic dermatitis or through its anti-inflammatory effects (especially reduction in the activities of histamine, LTB4, and IL-2, all of which have been implicated in the pathophysiology of itch.
How does Hypochlorous Acid (HOCl) fit into Eye Care?
As a natural compound it eliminates microorganisms on the skin and mucous membranes making it a very effective eyelid and eyelash cleaner. Hypochlorous Acid is well known for killing bacteria on the body, and this can be very beneficial for any inflammation that occurs with the eyelids, lashes, and the eyes themselves. By removing negative bacteria, this solution can help soothe conditions such as blepharitis, Meibomian gland dysfunction (MGD), and dry eye disease. After spraying the eye lid is now clean which help alleviate the signs and symptoms of blepharitis, dry eyes, and Meibomian gland dysfunction. No need to rinse! Due to this, many people notice less redness, improved comfort of the eyes, and better contact lens tolerance. Our Hypochlorous Acid for eyes is called PureLucid and should be used twice per day for maintenance of clean eyelids, to prevent sty’s. There is no bleach by-product in our product.
How does Hypochlorous acid (HOCl) fit into Dental Healthcare?
HOCl has been shown to be great for cleaning biofilm-contaminated implant surfaces, has the potential to be used during dental surgery, and is an effective oral rinse. Hypochlorous Acid (HOCl) has both proinflammatory and anti-inflammatory properties, and seems to play an important role in the immune system. The regulation of normal flora contributes to periodontal health, and HOCl seems to have the ability to attack Gram-negative pathogens during periodontitis. Our product is suitable as periodontal medication, as HOCl is an antimicrobial agent, inflammation modulator and healing promoter. Periodontitis is an inflammatory process initiated by plaque biofilm. See FAQ in biofilm. Ref: Mainnemare A, Megarbane B, Soueidan A, et al. Hypochlorous acid and taurine-N-monochloramine in periodontal diseases. J Dent Res. 2004;83(11):823–31.
How does Hypochlorous Acid take wound management to the next level?
Wound debridement is the foundation for healing in chronic wounds. Excessive debridement is a detriment to healing, whereas proper removal of accumulated non-viable tissue or foreign material from the wound bed maintains a healthy progressive healing trajectory and avoids wound chronicity.
How does Hypochlorous Acid take sanitation management to the next level?
As a sanitation chemical, once Hypochlorous Acid lands on a surface, it reacts with any germs or organic matter on that surface and then immediately deactivates, allowing for sanitation without requiring a post-rinse because no toxic chemicals are left behind. It should be continuously applied.
What is Hypochlorous Acid?
Because of its anti-microbial activity, HOCl is the perfect replacement for many antibiotics and antiseptics used in medicine today. Hypocholorous acid is an organic, completely natural substance released from the body’s neutrophil cells. HOCl functions in the body as an anti-microbial agent, and it also neutralizes bacteria, toxins, and inflammatory mediators in the body. It also works to prevent biofilm formation as well as deactivate problematic enzymes. As you can see, this important substance is a vital one for keeping the body healthy!