Pruritus is the most common symptom seen in dermatologic disease. HOCl is anti-inflammatory and reduces the activities of histamine, leukotriene B4, and interleukin-2, all of which are implicated in the pathophysiology of itch. HOCl may reduce pruritus either through its microbicidal effects upon cutaneous pathogens (especially Staphylococcus aureus in atopic dermatitis or through its anti-inflammatory effects (especially reduction in the activities of histamine, LTB4, and IL-2, all of which have been implicated in the pathophysiology of itch.