Chondroitin sulfate is a proteoglycan molecule which is a major component in cartilage. The chondroitin forms part of the mesh network of cartilage which provides cartilage with its resilient properties. Supplementary chondroitin can be taken up by the cartilage and assist in replacing damaged proteoglycan molecules. Supplementary chondroitin can also help reduce ongoing cartilage damage as the inflammatory enzymes’ breakdown the supplemented chondroitin rather than that present in the cartilage. Chondroitin is also absorbed orally and preferentially taken up by joints. Supplementation with chondroitin is also very safe.