Since humic substances have existed in nature well before human existence, research continues today to determine the benefits of Fulvic and Humic Acid. Most importantly, clinical documentation of both the short-term and long-term use and safety of Humic/Fulvic Acids is available. The Humate ingredients (Humic and Fulvic Acid) does not cause allergic reactions, anaphylaxis (unexpected reactions) to other medicines; it is an apyrogen.